Top Sinaloa cartel leaders, including son of El Chapo, taken into US custody: DOJ

Two top leaders of the Mexican Sinaloa drug cartel have been taken into custody by United States authorities to face charges for their role in leading the group's vast drug trafficking enterprise, the Department of Justice announced Thursday.

Sinaloa cartel co-founder Ismael "El Mayo" Zambada and Joaquin Guzman Lopez, the son of "El Chapo" Guzman, were placed under arrest in El Paso, Texas, on Thursday, according to Attorney General Merrick Garland.

"Both men are facing multiple charges in the United States for leading the Cartel's criminal operations, including its deadly fentanyl manufacturing and trafficking networks," Garland said in a statement. "El Mayo and Guzman Lopez join a growing list of Sinaloa Cartel leaders and associates who the Justice Department is holding accountable in the United States."

Zambada made his initial appearance Friday morning in El Paso federal court before Judge Anne Berton, according to court records. He pleaded not guilty to the 12 charges in his 2012 indictment in the Western District of Texas and was ordered detained pending his next hearing, scheduled for July 31, according to court records.

Zambada, 76, required the use of a wheelchair and made no other statements other than responding to Berton with "Yes," "No," or "Yes, I understand," as she questioned him, according to a transcript of the proceedings obtained by ABC News.

During the proceedings, Berton said that Ray Velarde, an attorney who plans to join the case, has an outstanding conflict in representing Zambada which the defendant would be permitted to waive if he chooses. The judge did not address the nature of the conflict.

Zambada faces multiple federal indictments in jurisdictions across the U.S. for his alleged role in the cartel and has been on the run from U.S. and Mexican law enforcement for years. His fellow co-founder of the Sinaloa cartel, Joaquín "El Chapo" Guzman, was extradited to the U.S. in 2017, convicted in 2019 and sentenced to life in prison.

"Today, the FBI and DEA arrested two alleged cartel leaders who have eluded law enforcement for decades. Ismael Mario 'El Mayo' Zambada García and Joaquin Guzman Lopez, son of El Chapo, will now face justice in the United States," FBI Director Christopher Wray said in a statement.

"Garcia and Guzman have allegedly overseen the trafficking of tens of thousands of pounds of cocaine, heroin, methamphetamine, and fentanyl into the U.S. along with related violence. These arrests are an example of the FBI's and our partners commitment to dismantling violent transnational criminal organizations like the Sinaloa Cartel," Wray said.

The men were arrested in an operation that ended on U.S. soil.

"El Mayo" thought he was headed to inspect a clandestine Mexican airfield, of which the Sinaloa cartel has many in the country. Instead, according to a Homeland Security Investigations official, a senior ranking member of the cartel tricked him and flew him to El Paso instead.

Upon landing on the tarmac, agents from HSI, along with the FBI arrested "El Mayo" and Guzman.

The HSI official tells ABC News the operation had been planned "for months."

They were placed in handcuffs by FBI agents during an operation culminating at an airstrip not far from El Paso.

"The arrest of Ismael Zambada García, better known as 'El Mayo,' one of the alleged founders and leaders of the Sinaloa Cartel, strikes at the heart of the cartel that is responsible for the majority of drugs, including fentanyl and methamphetamine, killing Americans from coast to coast. El Mayo is one of DEA's most wanted fugitives and he is in custody tonight and will soon face justice in a U.S. court of law," said Drug Enforcement Administration Administrator Anne Milgram.

"Joaquin Guzman Lopez, another alleged leader of the Sinaloa Cartel, and the son of 'El Chapo,' was also arrested today -- his arrest is another enormous blow to the Sinaloa Cartel. In 2017, he and his brothers, the Chapitos, allegedly took control of the Sinaloa Cartel after El Chapo was extradited to the United States. DEA will continue to seek justice for any American life that is lost and will work tirelessly to prevent more needless deaths and pursue those that are responsible," Milgram said.

Mexican President Andres Manuel Lopez Obrador called the arrests a "breakthrough" in the fight against the drug crisis impacting the U.S. in comments on Friday.

The Mexican government said was not aware that the two were going to be extradited to the U.S. to be arrested, Mexican authorities said during a press briefing on Friday.

The Mexican government received a phone call from the U.S. Embassy Thursday afternoon informing them the two were in custody in El Paso, the authorities said. The Mexican government has asked U.S. officials for pictures of the two men to confirm the information.

According to the flight plan, the private plane that was used to transport the two men traveled from Hermosillo, Sonora, to Santa Teresa, New Mexico, Mexican authorities said.

The U.S. government had offered a $15 million reward for information leading to the arrest and/or conviction of Zambada.

"Too many of our citizens have lost their lives to the scourge of fentanyl," President Joe Biden said in a statement Friday morning. "Too many families have been broken and are suffering because of this destructive drug. My Administration will continue doing everything we can to hold deadly drug traffickers to account and to save American lives."

Guzman Lopez's brother, Ovidio Guzman Lopez, was charged last year with two dozen others as part of a crackdown targeting a global drug trafficking network run through Mexico's Sinaloa cartel. According to the charges, the cartel used precursor chemicals shipped from China to fuel the fentanyl crisis plaguing the U.S.

Ovidio Guzman Lopez had been wanted by U.S. authorities since 2019 and was captured by Mexican armed forces in January 2023 in a small town just outside the city of Culiacán, the capital of the Mexican state of Sinaloa.

He was captured in an overnight raid that had been in the works for more than six months, officials said at the time. The arrest followed an infamous incident in 2019, in which authorities briefly detained Guzman Lopez at a home in Culiacán, before word spread and heavily armed gunmen flooded the city. Massive shootouts occurred between cartel members and Mexican armed forces around the city. Mexican President Andrés Manuel López Obrador ordered Guzman Lopez released in order to avoid more bloodshed.

Their father is serving a life sentence in the U.S. after being convicted in 2019 of conducting a continuing criminal enterprise, including large-scale narcotics violations and a murder conspiracy, drug trafficking conspiracies, unlawful use of a firearm and a money laundering conspiracy.