A fast-moving brush fire exploded over 14,000 acres on Wednesday, prompting evacuations amid a red flag warning from the National Weather Service.
Ventura County remains under an "extremely critical" wildfire warning while firefighters struggle to gain an edge on the Mountain Fire, which is currently 0% contained.
At least two individuals have been transferred to hospitals for smoke inhalation, Ventura County Fire Chief Justin Gardner said during a press briefing Wednesday evening.
An accurate number regarding damage is expected on Thursday, as the area remains too dangerous to fully assess the damage, according to Gardner.
At least 14,000 people were told to evacuate, Ventura County Sheriff Jim Fryhoff.
MORE: Wildfire smoke to worsen across US, putting 125 million at risk: StudyThe Mountain Fire is one of two wind-driven fires that broke out in Southern California, leading the NWS to issue a rare red flag warning for Los Angeles and Ventura Counties alerting of an "extreme fire risk" from Malibu into the San Gabriel Mountains, north of Los Angeles, where winds could gust near 100 mph.
"A very strong, widespread, and long-duration Santa Ana wind event will bring widespread extremely critical fire weather conditions to many areas of Los Angeles and Ventura counties Wednesday into Thursday," according to the NWS warning.
As of Wednesday, at least two wind-driven fires have already broken out in Southern California.
According to local fire officials, the rapidly burning Mountain Fire in Ventura County has spread over 14,000 acres, prompting evacuation orders, threatening structures, and leaving several people injured.
"We do know we've lost homes, we do know we’ve had homes damaged, and we know of injuries but I do not have any counts," Public Information Officer Scott Dettorre told ABC News.
"The injuries we do know of are civilian, we do not have any firefighter injuries at this time," Dettorre said.
Due to extreme wind conditions, fixed-wing aircraft are unable to assist in firefighting efforts, according to the Ventura Fire Department, which said ground crews, helicopters and mutual aid resources are "actively working to protect lives and property."
MORE: Artificial intelligence has 'revolutionized' modern firefighting: Here's howEvacuation orders are in effect for Walnut Ave to Balcom Canyon Road and North Highway 118 to the ridgeline and west to Saticoy County Club in Ventura County, according to CAL Fire.
A second wildfire erupted in Los Angeles County's Malibu area Wednesday -- named the Broad Fire -- and has burned at least 50 acres southwest of South Malibu Canyon Road and the Pacific Coast Highway (PCH) in Malibu, according to CAL Fire.
Local fire officials have warned residents to prepare for potential evacuations and the PCH has been closed in both directions between Webb Way and Corral Canyon.
Named after Southern California's Santa Ana Canyon, the region's Santa Ana winds bring blustery, dry and warm wind that blows out of the desert, drying out vegetation and increasing wildfire danger.
The long-duration Santa Ana wind event will reach its peak on Wednesday, becoming moderate on Thursday, then tailing off to light offshore winds on Friday.
Northeast winds moving 20 to 40 mph with gusts up to 60 mph are expected across the canyons and passes of Southern California through Wednesday, with higher winds in the more wind-prone areas.
Another surge of wind is expected to peak late Wednesday night through Thursday morning with widespread northeast winds of 20 to 30 mph with gusts to 50 mph before weakening considerably by Thursday afternoon.