Up to 5 inches of rain has slammed parts of Arkansas, Kentucky, Tennessee, West Virginia and Maryland, leaving residents stranded, roads washed out and buildings flooded.
In London, Kentucky, the London-Laurel County Rescue Squad used a raft to rescue a woman trapped in her car Sunday night.
In Salyersville, Kentucky, a nursing home evacuated its residents due to a high risk of flooding, the staff told local station WYMT-TV.
MORE: Authorities rescue 5 from truck trapped in flooded creek in TennesseeIn Powell County, Kentucky, all learning is remote on Monday due to the flooding.
Thunderstorms also brought damaging winds to Kentucky, Tennessee, Alabama and Mississippi, knocking down power lines and trees.
Officials are urging residents to drive with extra caution.
Although the heavy rain has subsided, flood warnings remain in effect Monday due to saturated grounds and swollen creeks and rivers.
The rain is now moving Southeast. Heavy rain is in the forecast through Wednesday morning from New Orleans, Louisiana, to Charleston, South Carolina.
MORE: 3 life-saving tactics to use if in a car during a flash floodThe heaviest rain will likely be Monday night through Tuesday night with scattered thunderstorms and isolated flash flooding. Some spots could see 2 to 4 inches of rain.
In the Northeast, arctic air is about to return.
Wind advisories and high wind warnings are in effect through Tuesday morning from Washington, D.C., to New York City to New England. Wind gusts could reach 50 to 60 mph.
By Tuesday morning, the wind chill -- what it feels like -- will plunge to -3 degrees in Boston, 12 degrees in New York City and 9 degrees in Pittsburgh.