Culture January 28, 2021

Katherine Heigl reacts to how Justin Chambers was written off 'Grey's Anatomy'

WATCH: Justin Chambers exits ‘Grey’s Anatomy’

Katherine Heigl may not be on "Grey's Anatomy" anymore, but that didn't stop her from offering up her opinion on the show's shocking twist involving Alex and Izzie last season.

During season 16, Justin Chambers' character, Alex Karev, left Seattle -- and his new wife, Jo (Camilla Luddington) -- to be with his ex-wife, Heigl's Izzie Stevens, so Chambers could be written off.

MORE: Ellen Pompeo reveals what she thought of Justin Chambers' 'Grey's Anatomy' exit

Speaking with Entertainment Tonight, the 42-year-old actress revealed she hadn't seen the episode -- which aired nearly a year ago on March 5, 2020.

"I didn't see it," she admitted before being brought up to speed on what happened.

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"Wasn't he with someone?" she then asked, adding, "Listen, isn't that an a------ move?"

Mike Rosenthal/ABC
ABC's "Grey's Anatomy" star Justin Chambers as Alex Karev.

The show is currently in season 17, which has seen the return of past stars like Patrick Dempsey (Derek Shepherd) and T.R. Knight (George O'Malley), but it doesn't seem that fans should expect Heigl to join them.

When asked if she would make a cameo, Heigl explained that she's "super focused" on her new show, "Firefly Lane."

MORE: Justin Chambers bids farewell to 'Grey's Anatomy' in bittersweet final episode

"I would never say never," she teased, but quickly stated that "it's not likely."

Alex and Izzie -- two of the show's original characters -- married in the 100th episode, which occurred during season five. Heigl departed the show in season six. Alex and Jo married in season 14, with Chambers leaving in season 16.